ASPSCR1 (arrow) was detected using the purified antibody ASPSCR1 Antibody flow cytometry of HeLa cells (right histogram) compared to a negative control cell (left histogram) FITCconjugated goatantirabbit secondary antibodies were used for the analysis ASPSCR1 (ASPSCR1 Tether For SLC2, UBX Domain Containing) is a Protein Coding gene Diseases associated with ASPSCR1 include Alveolar Soft Part Sarcoma and Renal Cell Carcinoma, Xp11AssociatedAmong its related pathways are Vesiclemediated transport and Translocation of GLUT4 to the plasma membraneAn important paralog of this gene is UBXN6Contains an UBX domain, which

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Aspscr1 protein
Aspscr1 protein-Symbol Description Category GIFtS GC id Score;31 ASPSCR1 Silencer Select Predesigned, Validated, and Custom siRNA in Standard, HPLC, and Invivo Ready Purities




Modeling Alveolar Soft Part Sarcoma Unveils Novel Mechanisms Of Metastasis Cancer Research
Aspscr1 2 Annotation score Annotation score1 out of 5 The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given proteinThe RNAsequencing results generated in the HPA are reported as normalized NX values In the Human Protein Atlas a NX value of 10 is defined as a threshhold for expression of the corresponding protein The cell lines are divided into colorcoded groups according to their origin in the human bodyIt sequesters GLUT4containing vesicles in the cytoplasm in absence of insulin
3 ASPSCR1 TEXT A number sign (#) is used with this entry because some cases of alveolar soft part sarcoma have been found to be caused by fusion of the ASPSCR1 () and TF () genes Description Alveolar soft part sarcoma is an unusual tumor with highly characteristic histopathology and ultrastructureAspscr1 ID ZDBGENE Name ASPSCR1 tether for SLC2, UBX domain containing Symbol aspscr1 Nomenclature History Previous Names zgc;1 ASPSCR1 ASPSCR1 Tether For SLC2, UBX Domain Containing Protein Coding 40 GC17P 47 2 TF Transcription Factor Binding To IGHM Enhancer 3
Functional Associations ASPSCR1 has 4,6 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 77 datasets ASPSCR1 470 Annotation score Annotation score1 out of 5 The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein ASPSCR1 (ASPSCR1 Tether For SLC2, UBX Domain Containing) is a Protein Coding gene Diseases associated with ASPSCR1 include Alveolar Soft Part Sarcoma and Renal Cell Carcinoma, Xp11AssociatedAmong its related pathways are Vesiclemediated transport and Translocation of GLUT4 to the plasma membraneVCP ASPSCR1 Affinity CaptureLuminescence
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Anti Aspscr1 Antibody Hpa Atlas Antibodies
OncoKB is a precision oncology knowledge base developed at Memorial Sloan Kettering Cancer Center that contains biological and clinical information about genomic alterations in cancerASPSCR1 A gene on chromosome 17q253 that encodes a ubiquitous tethering protein highly expressed in the testes, heart, skeletal muscle and pancreas; ASPL is a cofactor of the hexameric ATPase complex, known as p97 The central area in ASPL, containing both a SHP box and a UBX domain, is required for binding to the p97 Ndomain Results support a gainoffunction role for ASPSCR1TF contributing to proliferation and survival of cancer cells Promotes methylation of VCP by METTL21D



Kidney Renal Cell Carcinoma With T X 17 P11 Q25 Aspscr1 Tfe3




Anti Aspscr1 Antibody Rabbit Aspscr1 Polyclonal Antibody Q9bze9 1
AntiASPSCR1 Antibody (A0516) TUG (ASPSCR1) Human Recombinant Protein (PROTQ9BZE9) AntiCD34 (Cterm) Rabbit Monoclonal Antibody, Clone#RM300 (M0052) View all ASPSCR1 products Compatible Secondaries For Host Mouse ECL Detection Kit, Including HRPConjugated Goat AntiMouse IgG Antibody (EK1001)AntiASPSCR1 antibody (Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1) Primary Antibody ASPSCR1 Reactivity Human, Mouse, Rat IF, IHC, WB Host Rabbit Polyclonal unconjugated camera_alt 4Polyclonal Antibody to ASPSCR1 Figure 1 Western blot analysis of extracts from HL60 cells using ASPSCR1 Antibody 3516




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Aspscr1 Tfe3 Fusion Translocation Fish Probe Kit 10 Tests Diagnostic Technology
VCP ASPSCR1 Affinity CaptureLuminescence Affinity CaptureLuminescence An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tagTethering protein that sequesters GLUT4containing vesicles in the cytoplasm in the absence of insulin Modulates the amount of GLUT4 that is available at the cell surface (By similarity) Enhances VCP methylation catalyzed by VCPKMT The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4) This protein is a tether, which sequestersThe ASPSCR1TF Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human ASPSCR1 and TF genes located on chromosome bands 17q253 and Xp1123, respectively Fusion of ASPSCR1 – also known as TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9 or ASPCR1 – with the TF gene – also known as TFEA, RCCP2, RCCX1 or




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2
The reciprocal 5' TF 3' ASPSCR1 is most often absent ASPSCR1 is fused in frame to TF exon 3 or 4 Abnormal Protein NH2 term ASPSCR1, fused to the C term of TF Oncogenesis might combine the effect of a fusion protein to that of gene(s) dosage Entity primary renal ASPSCR1TF tumour DiseaseThis protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation Translocation t (X;17) (p11;q25) of this gene with transcription factor TF gene results in a ASPSCR1TF fusion protein in The ASPSCR1TF and ASPSCR1TFEB but not ASPSCR1TFEC and ASPSCR1MITF induced sarcoma The results suggest the presence of TF/TFEBspecific cofactors and mechanisms for tumorigenesis In order to identify such novel cofactors and functional motifs, human ASPS cellnuclear extract was incubated with TF or MITF proteins and TF or MITF



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